It depends.
You can renew some OverDrive titles three days before they are due to expire with a renew icon appearing next to the title on your Bookshelf under your library OverDrive account. If your eBook has accumulated holds then you will no longer see a “Renew” link for that title on your bookshelf. Instead, you will see a “Request Again” link that lets you join the title’s holds list and borrow the title again when it becomes available. For more information on renewing OverDrive titles or renewing on Libby.
Wheelers do not allow renewals.